#### Select GWAS

Filter GWAS

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to
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Minimum:
Maximum:
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**By trait categories**
Domain:

-- Please select Domain of interest --

Chapter level:

-- Please select Chapter of interest --

Subchapter level:

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**By trait****By published year**From

**By total sample size**Minimum:

#### 0 GWAS are selected.

select | ID | PMID | Year | Domain | Chapter level | Subchapter level | Trait | uniqTrait | Population | N |
---|

#### Summary of selected GWAS

#### Year vs Sample size

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#### Sample size vs Number of risk loci

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#### Sample size vs SNP heritability

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#### Number of risk loci vs SNP heritability

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#### Domain Color-code

#### Genetic Correlation

Sort traits by:
Alphabetically
Domain
Cluster

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The heatmap is symmetric. Significant genetic correlations after Bonferroni correction (< 0.05) are labeled with "*". Rectangles next to the trait labels are colored based on the domain of the trait.

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The heatmap is symmetric. Significant genetic correlations after Bonferroni correction (< 0.05) are labeled with "*". Rectangles next to the trait labels are colored based on the domain of the trait.

#### MAGMA genes overlap

Sort traits by:
Alphabetically
Domain
Cluster

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The heatmap is asymmetric. The cell of

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The heatmap is asymmetric. The cell of

*i*th column and*j*th row represents the proportion of overlapped significant genes (P-value < 2.5e-6) between two GWAS based on the number of significant genes in ith GWAS (the number of genes significant in both GWAS*i*and*j*divided by the number of significant genes in GWAS*i*). Rectangles next to the trait labels are colored based on the domain of the trait.#### Pleiotropic risk loci

Each dot represents a group of physically overlapping risk loci.
See Documentation for details.
The genome wide plot can be zoomed in and out by scroll.
When Y-axis is the number of associated domains, the dots are sized by the number of associated GWAS and vice versa.
Note that the number of associated GWAS is the number of associated unique summary statistics which does not necessary reflect the number of associated unique traits
when multiple summary statistics for a single trait are selected.
By clicking a dot, another plot for a specific group of risk loci will be plotted (only if the number of GWAS in the grouped locus is > 1).
Note that P-value < 1e-300 is replaced with 1e-300 (maximum -log10 P-value is 300 in this plot).

Y-axis:
Number of associated domains
number of associated GWAS

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Y-axis:

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#### Pleiotropic genes

Each dot represents a single gene.
The genome wide plot can be zoomed in and out by scroll.
When Y-axis is the number of associated domains, the dots are sized by the number of associated GWAS and vice versa.
Note that the number of associated GWAS is the number of associated unique summary statistics which does not necessary reflect the number of associated unique traits
when multiple summary statistics for a single trait are selected.
By clicking a dot, PheWAS plot of the selected gene for selected GWAS will be displayed below.
Note that P-value < 1e-300 is replaced with 1e-300 (maximum -log10 P-value is 300 in this plot).

Y-axis:
Number of associated domains
number of associated GWAS

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Y-axis:

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Sort traits by:
Alphabetically
P-value
Total sample size
Domain
Domain and P-value
Clear text labels

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